儿童代谢健康型肥胖的发病机制及预测指标

doi:10.3877/cma.j.issn.2095-9605.2022.01.009

儿童代谢健康型肥胖（MHO）是指体质量指数（BMI）达到儿童肥胖症标准，但尚未发现有代谢指标的异常。与代谢异常型肥胖（MUO）相比，MHO儿童未来发生高血压、高血脂、2型糖尿病等并发症的风险降低。确定MHO儿童的定义，阐明MHO的发病机制与预测因素，对儿童肥胖的分层管理及针对性治疗十分重要，有利于肥胖儿童的长期预后。目前关于儿童MHO的研究较少，本文就其发病机制及预测因素等方面进行综述，为进一步研究儿童MHO的早期诊断和预后判断提供新思路。

关键词: 儿童, 代谢健康型肥胖, 发病机制, 预测因素

Metabolically healthy obesity (MHO) in children is defined as the body mass index (BMI) meets the standard of childhood obesity, but no metabolic abnormalities have been found. Compared with metabolic abnormality obesity (MUO), children with MHO have a reduced risk of future complications such as hypertension, hyperlipidemia, and type 2 diabetes. It is important to define MHO children and clarify the pathogenesis and predictors of MHO for stratified management and targeted treatment of childhood obesity, which is beneficial to the long-term prognosis of obese children. At present, there are few studies on MHO in children. In this paper, the pathogenesis and predictive factors of MHO in children were reviewed, providing new ideas for further study on early diagnosis and prognosis of MHO in children.

Key words: Children, Metabolically healthy obesity, Pathogenesis, Predictors

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Pathogenesis and predictors of metabolically healthy obesity in children

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Pathogenesis and predictors of metabolically healthy obesity in children