切换至 "中华医学电子期刊资源库"

中华肥胖与代谢病电子杂志 ›› 2018, Vol. 04 ›› Issue (03) : 168 -172. doi: 10.3877/cma.j.issn.2095-9605.2018.03.010

所属专题: 文献

综述

肠道菌群参与代谢综合征的机制研究进展
王迎伟1,(), 莫双阳1, 李运泽1   
  1. 1. 545000 柳州,广西科技大学附属柳州市人民医院消化内科
  • 收稿日期:2018-05-08 出版日期:2018-08-30
  • 通信作者: 王迎伟

Advances in the mechanism study on intestinal fl ora involvement in metabolic syndrome

Yingwei Wang1(), Shuangyang Mo1, Yunze Li1   

  • Received:2018-05-08 Published:2018-08-30
  • Corresponding author: Yingwei Wang
引用本文:

王迎伟, 莫双阳, 李运泽. 肠道菌群参与代谢综合征的机制研究进展[J]. 中华肥胖与代谢病电子杂志, 2018, 04(03): 168-172.

Yingwei Wang, Shuangyang Mo, Yunze Li. Advances in the mechanism study on intestinal fl ora involvement in metabolic syndrome[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2018, 04(03): 168-172.

[1]
Ley RE,Turnbaugh PJ,klein S, et al. Microbial ecology: human gut microbes associated with obesity[J]. Nature, 2006, 21444(12):1022-1023.
[2]
Hu Xu,Wang Tao,Jin Feng. Alzheimers disease and gut microbiota[J]. Science China Life Sciences, 2016, 59(10):1006-1023.
[3]
Mishra AK,Dubey V,Ghosh AR. Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota[J]. Metabolism, 2016, 65(1):48-65.
[4]
Devaraj S,Hemarajata P,Versalovic J. The human gut microbiome and body metabolism: implications for obesity and diabetes[J]. Clinical Chemistry, 2013, 59(4):617-628.
[5]
Louis S,Tappu RM,Damms-Machado A, et al. Characterization of the gut microbial community of obese patients following a weight-loss intervention using whole metagenome shothun sequencing[J]. PLoS One, 2016, 11(2):e0149564.
[6]
Turnbaugh PJ,Ley RE,Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature, 2006, 444(7122):1027-1031.
[7]
Duca FA,Sakar Y,Covasa M, et al. Replication of obesity and associated singaling pathways through transfer of microbiota from obese-prone rats[J]. Diaetes, 2014, 63(5):1624-1636.
[8]
Chang CJ,Lin CS,Lu CC, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J]. Nature Communication, 2015, 6(7489): 1.
[9]
Vrieze A,Van Nood E,Holleman F,et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome[J]. Gastroenterology, 2012, 143(4):913-916.e7.
[10]
Koeth RA,Wang Z,Levison, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis[J]. Nature Medicine, 2013, 19:576-585.
[11]
Warrier M,Shih DM,Burrows AC, et al. The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance[J]. Cell Reports, 2015, 10:326-338.
[12]
Backhed F,Ding H,Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage[J]. PNAS, 2004, 101(44): 15718.
[13]
Xu H,Barnes GT,Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance[J]. Journal of Clinical Investigation, 2003, 112(12): 1821-1830.
[14]
Aron-Wisnewsky J,Gaborit B,Dutour A, et al. Gut microbiota and non-alcoholic fatty liver disease: new insights[J]. Clinical Microbiology and Infection, 2013, 19(4): 338-348.
[15]
Janero DR,Lindsley L,Vemuri VK, et al. Cannabinoid 1G Protein-coupled receptor (periphero-) neutral antagonists: emerging therapeutics for treating obesity-driven metabolic diease and reducing cardiovascular risk[J]. Expert Opinion on Drug Discovery, 2011, 6(10): 995-1025.
[16]
Trillou CR,Delgorge C,Menet C, et al. CBI cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced onesity and enhanced leptin sensitivity[J]. Int J Obes(Lond), 2004, 28(4):640-648.
[17]
Cani PD,Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease[J]. Current Pharmaceutical Design, 2009, 15(13):1546-1558.
[18]
Larsen N,Vogensen FK,Van den Berg FW, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults[J]. PLoS One, 2010, 5(2):e9085.
[19]
Zhang Xiuying,Shen Dongyuan,Fang Zhiwei, et al. Human gut microbiota changes reveal the progression of glucose intolerance[J]. PLoS One, 2013, 8(8):e71108.
[20]
Hartstra AV,Bouter KE,Nieuwdorp M, et al. Insights into the role of the microbiome in obesity and type 2 diabetes[J]. Diabetes Care, 2015, 38(1):159-165.
[21]
Qin Junjie,Li Yingrui,Wang Jun. A metagenome-wide association study of gut microbiota in tape 2 diabetes[J]. Nature, 2012, 490(7418):55-60.
[22]
Forslund K,Hildebrand F,Nielsen T, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J]. Nature, 2015, 528(7581):262.
[23]
Sato J,Kanazawa A,Ikeda F, et al. Gut dysbiosis and etection of "Live Gut Bacteria" in biood of Japanese patients with type 2 diabetes[J]. Diabetes Care, 2014, 37(8):2343-2350.
[24]
Hill JH,Franzosa EA,Huttenhower C,Guillemin K. A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development[J]. Elife, 2016, 13:5.
[25]
Batterham RL,Cowley MA,Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake[J]. Nature, 2002, 418(6898):650-654.
[26]
Nadkarni P,Chepurny OG,Holz GG. Regulation of glucose homeostasis by GLP1[J]. Progress in Molecular Biology & Translational, 2014, 121:23-65.
[27]
Lin HV,Frassetto A,Kowalik EJ Jr, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms[J]. PLoS One, 2012, 7(4):e35240.
[28]
Cani PD,Amar J,Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance[J]. Diabetes, 2007, 56(7):1761-1772.
[29]
Caricilli AM,Picardi PK,de Abreu LL, et al. Gut microbiota Is a key modulator of insulin resistance in TLR 2 knockout mice[J]. PLoS Biology, 2011, 9(12):e1001212.
[30]
Li Fei,Jiang Changtao,Krausz KW, et al. Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity[J]. Nature Communication, 2013, 4:2384.
[31]
Stenman LK,Holma R,Korpela R. High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids[J]. World J Gastroenterol, 2012, 18(9):923-929.
[32]
Yang T,Santisteban MM,Rodriguez V, et al. Gut dysbiosis is linked to hypertension[J]. Hypertension, 2015, 65(6):1331-1340.
[33]
Nutting CW,Islam S,Daugirdas JT. Vasorelaxant effect of short chain fatty acid salts in rat caudal artery[J]. American Journal of Physiology, 1991, 261:H561-567.
[34]
Holmes E,Loo RL,Stamler J, et al. Human metabolic phenotype diversity and its association with diet and blood pressure[J]. Nature, 2008, 453:396-400.
[35]
Gomez-Guzman M,Toral M,Romero M, et al. Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats[J]. Molecular Nutrition & Food Research, 2015, 59(11):2326-2336.
[36]
Forythe P,Kunze W,Bienenstock J. Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis[J]. BMC Medicine, 2016, 14(1):58.
[37]
Angelakis E,Armougom F,Million M, et al. The relationship between gut microbiota and weight gain in human[J]. Future Microbiol, 2012, 7(1):91-109.
[38]
Manzanares W,Lemieux M,Langlois PL, et al. Probiotic and symbiotic therapy incritical illness[J]. Critical Care, 2016, 20(1):262.
[39]
Everard A,Lazarevic V,Derrien M, et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice[J]. Diabetes, 2011, 60(11):2775-2786.
[40]
Bakken JS,Borody T,Brandt LJ, et al. Treating Clostridium difficile infection with fectal microbiota transplantion[J]. Clin Gastroenterol Hepatol, 2011, 9(12):1044-1049.
[41]
Young VB. Treatment with fecal microbiota transplantation: the need for complete methodological reporting for clinical trials[J]. Annals of Internal Medicine, 2017.doi:10.7326/M17-1157.
[42]
Khoruts A,Weingarden AR. Emergence of fecal microbiota transplantation as an approach to repair disrupted microbial gut ecology[J].Immunology Letters, 2014, 162(2 Pt A):77-81.
[43]
Woodard GA,Encarnacion B,Downey JR, et al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial[J]. Journal of Gastrointestinal Surgery, 2009, 13(7):1198-1204.
[44]
Liou AP,Paziuk M,Luevano JM, et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity[J]. Science Translational Medicine, 2013, 5(178):178ra41.
[1] 郑希彦, 周正, 何方平, 林志群, 杜飞, 谢琴, 王少平, 史宪杰. 代谢综合征与乙型肝炎病毒相关性肝细胞癌预后的危险因素分析[J]. 中华普通外科学文献(电子版), 2023, 17(02): 104-109.
[2] 李丹阳, 李满祥. 肠道菌群失调在肺动脉高压发病中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 432-434.
[3] 何吉鑫, 杨燕妮, 王继伟, 李建国, 谢铭. 肠道菌群及肠道代谢产物参与慢性便秘发生机制的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 495-499.
[4] 乔小梅, 孔凯丽, 方敬爱, 张晓东. "肠-皮肤轴"与尿毒症皮肤病变的关系研究进展[J]. 中华肾病研究电子杂志, 2023, 12(05): 291-294.
[5] 李娜, 朱国贞. 肠道菌群及其代谢产物在急性肾损伤中的作用研究进展[J]. 中华肾病研究电子杂志, 2023, 12(04): 215-219.
[6] 王宁, 刘彦哲, 吴紫莺, 曾超, 雷光华, 沙婷婷, 王伊伦. 基于孟德尔随机化研究探讨肠道菌群与肌少症表型的因果关联[J]. 中华老年骨科与康复电子杂志, 2023, 09(06): 333-342.
[7] 屈霄, 王靓, 陆萍, 何斌, 孙敏. 外周血炎症因子及肠道菌群特征与活动性溃疡性结肠炎患者病情的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 466-470.
[8] 孙晗, 武侠. 成人肠易激综合征患者肠道菌群特征与不同分型患者生活质量和精神症状的相关性[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 461-465.
[9] 廖想, 李爽, 曾瑶. 2012-2021年粪菌移植研究的趋势及热点分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(02): 93-99.
[10] 张大涯, 陈世锔, 陈润祥, 张晓冬, 李达, 白飞虎. 肠道微生物群对代谢相关脂肪性肝病发展的影响[J]. 中华临床医师杂志(电子版), 2023, 17(07): 828-833.
[11] 韩家超, 王飞飞, 柳子宁, 胡冀陶, 孟泽松, 雒月云, 王贵英. 二甲双胍的作用机制研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(03): 349-355.
[12] 杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞. 肠道菌群促进诺如病毒感染的机制[J]. 中华临床实验室管理电子杂志, 2023, 11(04): 241-244,255.
[13] 刘艳, 唐神结. 肠道菌群与抗结核药及其所致肝损伤的相关性研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 82-86.
[14] 晋连超, 杨冰, 周哲, 潘东亮, 谢遵珂. 代谢综合征与女性压力性尿失禁相关性研究[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 109-113.
[15] 金泽平, 董晶, 柳云鹏, 汪阳. 菌群-肠道-脑轴与缺血性卒中危险因素关系的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 510-517.
阅读次数
全文


摘要