| [1] |
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults [J]. Lancet,2017,390(10113):2627-2642.
|
| [2] |
Chen K, Shen Z, Gu W, et al. Prevalence of obesity and associated complications in china: a cross-sectional, real-world study in 15.8 million adults [J]. Diabetes Obesity & Metabolism, 2023, 25(11): 3390-3399.
|
| [3] |
Xia C, Dong X, Li H, et al. Cancer statistics in china and united states, 2022: profiles, trends, and determinants [J].Chinese Medical Journal, 2022, 135(5): 584-590.
|
| [4] |
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA: a cancer journal for clinicians, 2021, 71(3): 209-249.
|
| [5] |
Zhou S, Zhao Z, Wang Z, et al. Cancer-associated fibroblasts in carcinogenesis [J]. Journal of Translational Medicine, 2025, 23(1): 50.
|
| [6] |
Su S, Chen J, Yao H, et al. CD10+ GPR77+ Cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness [J]. Cell, 2018, 172(4): 841-856. e16.
|
| [7] |
Demark-Wahnefried W, Rogers LQ, Gibson J T, et al. Randomized trial of weight loss in primary breast cancer: impact on body composition, circulating biomarkers and tumor characteristics [J]. International Journal of Cancer, 2020, 146(10): 2784-2796.
|
| [8] |
Balaban S, Shearer RF, Lee LS, et al. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration [J]. Cancer Metab, 2017, 5: 1.
|
| [9] |
Tovar-Hernández K, Salinas-Vera YM, Carlos-Reyes á, et al. Adipocytes reprogram the proteome of breast cancer cells in organotypic three-dimensional cell cultures [J]. Sci Rep, 2024, 14(1): 27029.
|
| [10] |
Delort L, Bougaret L, Cholet J, et al. Hormonal therapy resistance and breast cancer: involvement of adipocytes and leptin [J]. Nutrients, 2019, 11(12): 2839.
|
| [11] |
Wang T, Fahrmann JF, Lee H, et al. Jak/stat3-regulated fatty acid beta-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance [J]. Cell Metabolism, 2018, 27(1): 136-150.
|
| [12] |
Lu H, Clauser KR,Tam WL, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages [J]. Nature Cell Biology, 2014, 16(11): 1105-1117.
|
| [13] |
Springer NL, Iyengar NM, Bareja R, et al. Obesity-associated extracellular matrix remodeling promotes a macrophage phenotype similar to tumor-associated macrophages [J]. American Journal of Pathology, 2019, 189(10): 2019-2035.
|
| [14] |
Burke RM, Madden KS, Perry SW, et al.Tumor-associated macrophages and stromal tnf-alpha regulate collagen structure in a breast tumor model as visualized by second harmonic generation [J]. Journal of Biomedical Optics, 2013, 18(8): 86003.
|
| [15] |
Orlandini LF, Pimentel FF, Andrade JM, et al. Obesity and high neutrophil-to-lymphocyte ratio are prognostic factors in non-metastatic breast cancer patients [J]. Brazilian Journal of Medical and Biological Research, 2021, 54(10): e11409.
|
| [16] |
Bousquenaud M, Fico F, Solinas G, et al. Obesity promotes the expansion of metastasis-initiating cells in breast cancer [J]. Breast Cancer Research, 2018, 20(1): 104.
|
| [17] |
Reggiani F, Labanca V, Mancuso P, et al. Adipose progenitor cell secretion of gm-csf and mmp9 promotes a stromal and immunological microenvironment that supports breast cancer progression [J]. Cancer Research, 2017, 77(18): 5169-5182.
|
| [18] |
Okwan-Duodu D, Umpierrez GE, Brawley OW, et al. Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages [J]. American Journal of Cancer Research, 2013, 3(1): 21-33.
|
| [19] |
Gibson JT, Orlandella RM, Turbitt WJ, et al. Obesity-associated myeloid-derived suppressor cells promote apoptosis of tumor-infiltrating cd8+ t cells and immunotherapy resistance in breast cancer [J]. Frontiers in Immunology, 2020, 11: 590794.
|
| [20] |
Clements VK, Long T, Long R, et al. Frontline science: high fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells [J]. J Leukoc Biol, 2018, 103(3): 395-407.
|
| [21] |
Takada K, Kashiwagi S, Asano Y, et al. Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy [J]. Bmc Cancer, 2021, 21(1): 1129.
|
| [22] |
Neumann S, Campbell K, Woodall MJ, et al. Obesity has a systemic effect on immune cells in naïve and cancer-bearing mice [J]. International Journal of Molecular Sciences, 2021, 22(16): 8803.
|
| [23] |
Ali HR, Provenzano E, Dawson SJ, et al. Association between cd8+ t-cell infiltration and breast cancer survival in 12 439 patients [J]. Annals of Oncology, 2014, 25(8): 1536-1543.
|
| [24] |
Kado T, Nawaz A, Takikawa A, et al. Linkage of cd8+ t cell exhaustion with high-fat diet-induced tumourigenesis [J]. Sci Rep, 2019, 9(1): 12284.
|
| [25] |
Beyer M, Abdullah Z, Chemnitz JM, et al. Tumor-necrosis factor impairs cd4+ t cell-mediated immunological control in chronic viral infection [J]. Nature Immunology, 2016, 17(5): 593-603.
|
| [26] |
de Andrade AG, Vanderley S, de Farias ML, et al. Leptin, nk cells, and the weight of immunity: insights into obesity [J]. International Immunopharmacology, 2025, 147: 113992.
|
| [27] |
Lee Y, Tukei KL, Fang Y, et al.Obesity alters the vascular morphology and vegf-a signaling in adipose tissue [J]. FASEB Bioadv, 2025, 7(6): e70018.
|
| [28] |
Gonzalez-Perez RR, Lanier V, Newman G.Leptin's pro-angiogenic signature in breast cancer [J]. Cancers (Basel), 2013, 5(3): 1140-1162.
|
| [29] |
Hillers-Ziemer LE, Arendt LM. Weighing the risk: effects of obesity on the mammary gland and breast cancer risk [J]. J Mammary Gland Biol Neoplasia, 2020, 25(2): 115-131.
|
| [30] |
Gu JW,Young E, Patterson SG, et al. Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice [J]. Cancer Biology & Therapy, 2011, 11(10): 910-917.
|
| [31] |
Xu J, Ding L, Mei J, et al. Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments [J]. Signal Transduct Target Ther, 2025, 10(1): 268.
|
| [32] |
Arendt LM, McCready J, Keller PJ, et al. Obesity promotes breast cancer by ccl2-mediated macrophage recruitment and angiogenesis [J]. Cancer Research, 2013, 73(19): 6080-6093.
|
| [33] |
Kolb R, Kluz P, Tan ZW, et al. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 [J]. Oncogene, 2019, 38(13): 2351-2363.
|
| [34] |
Jimenez T, Friedman T, Vadgama J, et al. Nicotine synergizes with high-fat diet to induce an anti-inflammatory microenvironment to promote breast tumor growth [J]. Mediators Inflamm, 2020, 2020: 5239419.
|
| [35] |
Sofi S, Jan N, Masoodi G, et al. Combating chemoresistance in breast cancer: exploring tumour microenvironment, combination therapies and drug repurposing strategies [J]. Journal of Drug Targeting, 2025: 1-22.
|
| [36] |
Seo BR, Bhardwaj P, Choi S, et al. Obesity-dependent changes in interstitial ecm mechanics promote breast tumorigenesis [J]. Science Translational Medicine, 2015, 7(301): 130r-301r.
|
| [37] |
Zhang Y, Baloglu FK, Ziemer L, et al. Factors associated with obesity alter matrix remodeling in breast cancer tissues [J]. Journal of Biomedical Optics, 2020, 25(1): 1-14.
|
| [38] |
Conklin MW, Eickhoff JC, Riching KM, et al. Aligned collagen is a prognostic signature for survival in human breast carcinoma [J]. American Journal of Pathology, 2011, 178(3): 1221-1232.
|
| [39] |
Levental KR, Yu H, Kass L, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling [J]. Cell, 2009, 139(5): 891-906.
|
| [40] |
Pastel E, Price E, Sjoholm K, et al. Lysyl oxidase and adipose tissue dysfunction [J]. Metabolism-Clinical and Experimental, 2018, 78: 118-127.
|
| [41] |
Hillers-Ziemer LE, Kuziel G, Williams AE, et al. Breast cancer microenvironment and obesity: challenges for therapy [J]. Cancer Metastasis Rev, 2022, 41(3): 627-647.
|
| [42] |
Wishart AL, Conner SJ, Guarin JR, et al. Decellularized extracellular matrix scaffolds identify full-length collagen vi as a driver of breast cancer cell invasion in obesity and metastasis [J]. Science Advances, 2020, 6(43): eabc3175.
|